Josef T. Vitkouski
Josef T. Vitkouski (nome orijinal Joseph T. Witkowski) (*1943-†2008) ia es un cimiste american [1]. Inventor 20 patenta a rexersa cancerosa.
Lias[edita | edita la fonte]
Mercedes Fuertes, Joseph T. Witkowski, David G. Streeter, and Roland K. 1974 Robins Synthesis and enzymic activity of 1,2,4-triazole-3-carboxamide 6'-deoxyhomoribonucleoside-6'-phosphonic acid and related compounds J. Med. Chem 17( 6): 642–645
Pickering MV, Witkowski JT, Robins RK.1976 Synthesis of 1-(4-thio-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide. J Med Chem. 1 19(6):841-2. doi: 10.1021/jm00228a022
Sidwell RW, Allen LB, Khare GP, et al.1973 Effect of 1-beta-D-ribofuranosyl1-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on herpes and vaccinia keratitis and encephalitis in laboratory animals.Antimicrob Agents Chemother. 3(2): 242-246
Srivastava PC, Pickering MV, Allen LB, Streeter DG, Campbell MT, Witkowski JT, Sidwell RW, Robins RK.1977 Synthesis and antiviral activity of certain thiazole C-nucleosides. J Med Chem. 20(2):256-62
Streeter DG, Witkowski JT, Khare GP, Sidwell RW, Bauer RJ, Robins RK, Simon LN. 1973 Mechanism of action of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc Natl Acad Sci U S A. 70(4):1174-8 PMC
Huffman JH, Sidwell RW, Khare GP, Witkowski JT, Allen LB, Robins RK. In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother. 1973;3(2):235-241