Azol de Vitkouski

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azol de vitkouski e un medisin contra virus. La strutur ia es prima descriveda en 1971 par J. T. Witkowski

Termas tecnical[edita | edita la fonte]

1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-hydroxymethyl-oxolan-2-yl]-1,2,4-triazol-3-carboxamid

Nomes[edita | edita la fonte]

Ribavirin [2][3]

Lias[edita | edita la fonte]

sintese

Sander et al. 2020 Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19) A Review JAMA

Streeter, D. G., Witkowski, J. T., Khare, G. P., Sidwell, R. W., Bauer, R. J., Robins, R. K., & Simon, L. N. (1973). Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proceedings of the National Academy of Sciences of the United States of America, 70(4), 1174–1178. https://doi.org/10.1073/pnas.70.4.1174

Referes[edita | edita la fonte]

  1. Effects of ribavirin on cytokine production of recall antigens and phytohemaglutinin-stimulated peripheral blood mononuclear cells. (Inhibitory effects of ribavirin on cytokine production)
  2. Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides
  3. Huffman JH, Sidwell RW, Khare GP, Witkowski JT, Allen LB, Robins RK. 1973 In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother. 3(2):235-241. doi:10.1128/AAC.3.2.235